Complex Granulation

Engineered granules for flow, compressibility, and uniformity

Complex granulation process
Capability

Granulation Engineered for Manufacturability

Our complex granulation processes deliver uniform density, flow, and compressibility for seamless downstream processing. Wet and dry granulation approaches are selected based on active properties and target product profiles.

Flowability
Optimized for high-speed tableting and encapsulation
Content Uniformity
Controlled PSD and blending performance
Density
Targeted bulk and tapped density for dose accuracy
Scalability
Process parameters locked via QbD and DoE

Applications & Benefits

  • API layering: Uniform distribution and controlled release of actives
  • Moisture management: Controlled solvent and moisture profiles for stability
  • Mechanical strength: Robust granules to minimize attrition and fines
  • Compatibility: Tailored binder systems for diverse actives and excipients

Process & Quality Controls

  • Process analytics: In-process density, moisture, and particle size monitoring
  • Validation: Documented scale-up parameters and cleaning validation
  • Documentation: Full batch records, CoAs, and traceability for every lot
  • Integration: Smooth handoff to finished dosage form manufacturing